Neurons modeling a subset of those in the basal ganglia were tested, because the basal ganglia region is 1 of 2 brain regions that displays the greatest T1-dependent signal hyperintensity changes. This preclinical study was devised to investigate potential cellular toxicity in human neurons induced by gadolinium-based contrast agents (GBCAs) used for contrast-enhanced magnetic resonance imaging (MRI). Bower, MD, PhD, Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, University Hospital of Bern, University of Bern, FreiburgstraBern, Switzerland. The authors declare no conflicts of interest.Ĭorrespondence to: Danielle V. This study was funded by the Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, University Hospital of Bern, University of Bern, Bern, Switzerland. The experiments measuring oxygen consumption and acidification were performed in the laboratory of Stefan Freigang in the Institute of Pathology at the University of Bern. Imaging was conducted at the Live Cell Imaging Core Facility of the Microscopy Imaging Center at the University of Bern. This work was performed in the laboratory for Experimental Radiology, Inselspital, University Hospital of Bern, located in the Department for BioMedical Research (DBMR), University of Bern. All authors discussed the results and approved the final manuscript. validated reproducibility of quantifications as a second reader. conceived the experimental plans, designed the protocols, conducted the experiments, analyzed the data, and produced the final figures. Runge share the senior authorship.Īuthor contributions: D.V.B. Received for publication Januand accepted for publication, after revision, March 1, 2019. †Department for BioMedical Research, University of Bern, Bern, Switzerland. From the *Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, University Hospital of Bern and
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